Differentiation of heterozygotes in recessive albinism.

Differentiation of heterozygotes in recessive albinism.

Skin pigmentation was measured by reflectance spectrophotometry in 43 albinos, 44 of their relatives, and 123 random controls among Swazi subjects in southern Africa. Mean reflectance of the subject groups diminishes in the sequence affected subjects, obligate heterozygotes, other unaffected family members, random subjects, and the differences among the unaffected groups are highly significant....

Recessive albinism in three children and both parents.

Female Fecundity of Drosophila Melanogaster Second Chromosome Recessive Lethal Heterozygotes in Homozygous and Heterozygous Genetic Background.

Received August 26. 1964 A large number of both spontaneous and induced second chromosome recessive lethals in Drosophila melanogaster have been reported. Almost of all these lethals are rather rapidly eliminated from populations under random mating conditions. IVES (1945) and WALLACE (1950) have estimated the number of second chromosome loci of lethal genes as 495 and 400, respectively. Some l...

Apparent digenic inheritance of Waardenburg syndrome type 2 (WS2) and autosomal recessive ocular albinism (AROA).

Waardenburg syndrome (WS) is a clinically and genetically heterogeneous disease accounting for >2% of the congenitally deaf population. It is characterized by deafness in association with pigmentary anomalies and various defects of neural crest-derived tissues. At least four types are recognized (WS1, WS2, WS3 and WS4) on the basis of clinical and genetic criteria. Two previously described fami...

Albinism, Partial Albinism, and Vitiligo

Albinism, partial albinism, and vitiligo are three clinically distinct conditions having in common a deficiency of melanin pigment. As such they present the physician with the same basic problems-cosmetically disfiguring lesions and extreme sensitivity to sunlight of the involved areas. None of the diseases is itself an immediate threat to life, but the social disabilities, especially among dar...